Clinical Science of Nutrition
Original Article

Effects of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on the body composition and muscle strength in the elderly

1.

Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey

2.

Department of Geriatrics, Ege University School of Medicine, İzmir, Turkey

3.

Department of Radiation Oncology, Gazi University School of Medicine, Ankara, Turkey

4.

Department of Anesthesiology and Critical Care, Atatürk Training and Research Hospital, Ankara, Turkey

5.

Department of Radiation Oncology, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Turkey

6.

Department of General Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey

7.

Department of General Surgery, Karadeniz Technical University School of Medicine, Trabzon, Turkey

8.

Department of Radiation Oncology, Erciyes University School of Medicine, Kayseri, Turkey

9.

Department of Chest Surgery, University of Medical Sciences, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Turkey

10.

Department of Ear, Nose and Throat, Adana Numune Training and Research Hospital, Adana, Turkey

11.

Department of Neurology, University of Medical Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

12.

Department of Neurology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey

13.

Department of Chest Surgery, Bezmialem Vakıf Gureba University Hospital, İstanbul, Turkey

14.

Department of Medical Oncology, Uludağ University School of Medicine, Bursa, Turkey

15.

Department of General Surgery, University of Medical Sciences, Dışkapı Yıldırım Beyazıt Research Hospital, Ankara, Turkey

16.

Department of Anestesiology, Eskişehir Acıbadem Hospital, Eskişehir, Turkey

17.

Department of Neurology, Fatih Sultan Mehmet Research Hospital, İstanbul, Turkey

18.

Department of Internal Medicine, Division of Geriatrics, Erciyes University School of Medicine, Kayseri, Turkey

19.

Department of General Surgery, University of Medical Sciences, Gülhane Medical Faculty, Ankara, Turkey

20.

Department of Internal Medicine, Division Geriatrics, Şevket Yılmaz Training and Research Hospital, İstanbul, Turkey

Clin Sci Nutr 2019; 1: 67-74
DOI: 10.5152/ClinSciNutr.2019.892
Read: 386 Downloads: 122 Published: 02 September 2019

Objective: Oral amino-acid-combination supplements have become a common intervention to maintain or potentially increase the lean body mass (LBM) in the elderly. Our aim was to determine the tolerance and efficacy of the 8-week beta-hydroxy beta-methylbutyrate/arginine/glutamine (HMB/Arg/Gln) supplementation on anthropometrics, LBM, muscle strength, and gait speed in elderly patients.

Methods: In this longitudinal observational study, a total of 131 elderly patients were evaluated at two consecutive visits, including baseline (Week 0) and single follow-up (Week 8). The use of HMB/Arg/Gln was evaluated in terms of patient compliance, the efficacy on anthropometrics, LBM (kg, measured with bioelectrical impedance analysis-BIA), muscle strength (kg), gait speed, and safety.

Results: The mean (standard deviation, SD) age was 74.7 (6.8) years (57.3% of participants were males). Of the patients were diagnosed with malnutrition (according to the Subjective Global Assessment test). The main indications for the HMB/Arg/Gln supplementation were sarcopenia (45.8%) and cancer cachexia (42.0%). Only two patients stopped supplementation because of taste problem (1.5%). Overall, 79.4% of patients were still on HMB/Arg/Gln at the follow-up. The mid-upper-arm circumference (MUAC, 25.3–27.0 cm, p=0.017), mid-upper-arm muscle circumference (MUAMC, 21.7–22.2 cm, p=0.006), hand grip strength (16.0–19.0 kg, p=0.0001), and gait speed (0.5–0.7 m/sec, p=0.008) were increased after the HMB/Arg/Gln supplementation. The adverse events were reported in 14 (10.7%) patients. No serious adverse events were reported in association with HMB/Arg/Gln.

Conclusion: Our findings showed that 8 weeks of the HMB/Arg/Gln supplementation applied twice daily were well tolerated and safe in the elderly. The supplementation seems to improve the MUAC, MUAMC, muscle strength, and gait speed.

Cite this article as: Saka B, Şahin S, Kılıç D, Öztürk L, Yılmaz H, Doğanay M, et al. Effects of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on the body composition and muscle strength in the elderly. Clin Sci Nutr 2019; 1(2): 67-74.

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ISSN2667-6222 EISSN 2667-6230
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